{"version":"https://jsonfeed.org/version/1","title":"Guanine Medical Inc.","home_page_url":"https://guaninemedical.com","description":"Guanine Medical Inc.","author":{"name":"Guanine Medical Inc."},"items":[{"id":"https://guaninemedical.com/become-a-member/f/scientists-finally-watch-a-dna-repair-motor-untangle-its-knot","html_content":"

Our genome is full of knots hiding in plain sight. Wherever DNA sequences are rich in guanine, the strand can fold back on itself into a four-stranded tangle called a G-quadruplex, or G4. As I always say, these structure...

","url":"https://guaninemedical.com/become-a-member/f/scientists-finally-watch-a-dna-repair-motor-untangle-its-knot","title":"Scientists Finally Watch a DNA Repair Motor Untangle Its Knot","summary":"Our genome is full of knots hiding in plain sight. Wherever DNA sequences are rich in guanine, the strand can fold back on itself into a four-stranded tangle called a G-quadruplex, or G4. As I always say, these structure...","date_modified":"2026-08-15T21:21:42Z"},{"id":"https://guaninemedical.com/become-a-member/f/a-dna-knot-that-fights-covid-19-from-two-directions-at-once","html_content":"

What if the cure for a virus was made of the same basic building block as our own genetic code, just arranged into a shape the virus can't handle? That's the surprising idea behind a new study published in Nature Cell De...

","url":"https://guaninemedical.com/become-a-member/f/a-dna-knot-that-fights-covid-19-from-two-directions-at-once","title":"A DNA Knot That Fights COVID-19 From Two Directions at Once","summary":"What if the cure for a virus was made of the same basic building block as our own genetic code, just arranged into a shape the virus can't handle? That's the surprising idea behind a new study published in Nature Cell De...","date_modified":"2026-08-03T23:01:45Z"},{"id":"https://guaninemedical.com/become-a-member/f/the-dna-knot-behind-a-rare-blood-disorder","html_content":"

Some of the most important discoveries in biology come from asking a simple question that nobody had quite pinned down: if a gene is broken, why does it only cause problems in some cells and not others? A new study publi...

","url":"https://guaninemedical.com/become-a-member/f/the-dna-knot-behind-a-rare-blood-disorder","title":"The DNA Knot Behind a Rare Blood Disorder","summary":"Some of the most important discoveries in biology come from asking a simple question that nobody had quite pinned down: if a gene is broken, why does it only cause problems in some cells and not others? A new study publi...","date_modified":"2026-07-18T01:33:54Z"},{"id":"https://guaninemedical.com/become-a-member/f/the-hidden-genetic-switch-that-might-explain-how-insulin-turns-on","html_content":"

Every gene has an on/off switch, but scientists are increasingly finding that DNA doesn't just carry a linear code; it also folds into strange three-dimensional shapes that can influence whether a gene fires up. A new st...

","url":"https://guaninemedical.com/become-a-member/f/the-hidden-genetic-switch-that-might-explain-how-insulin-turns-on","title":"The Hidden Genetic Switch That Might Explain How Insulin Turns On","summary":"Every gene has an on/off switch, but scientists are increasingly finding that DNA doesn't just carry a linear code; it also folds into strange three-dimensional shapes that can influence whether a gene fires up. A new st...","date_modified":"2026-07-06T02:36:34Z"},{"id":"https://guaninemedical.com/become-a-member/f/new-approach-reveals-how-mutations-alter-rna-drug-binding","html_content":"

Small molecules that bind RNA offer promising therapeutic strategies, particularly for diseases like cancer, where genes are difficult to regulate through conventional protein-targeting drugs. Many of these RNA structure...

","url":"https://guaninemedical.com/become-a-member/f/new-approach-reveals-how-mutations-alter-rna-drug-binding","title":"New Approach Reveals How Mutations Alter RNA-Drug Binding ","summary":"Small molecules that bind RNA offer promising therapeutic strategies, particularly for diseases like cancer, where genes are difficult to regulate through conventional protein-targeting drugs. Many of these RNA structure...","date_modified":"2026-06-18T02:47:25Z"},{"id":"https://guaninemedical.com/become-a-member/f/dna-typos-rewire-genes-and-connect-metabolic-diseases-to-cancer","html_content":"

Millions of people worldwide live with metabolic syndrome; the cluster of conditions including obesity, high blood sugar, and insulin resistance that raises the risk of diabetes, fatty liver disease, and, less obviously,...

","url":"https://guaninemedical.com/become-a-member/f/dna-typos-rewire-genes-and-connect-metabolic-diseases-to-cancer","title":"DNA Typos Rewire Genes and Connect Metabolic Diseases to Cancer","summary":"Millions of people worldwide live with metabolic syndrome; the cluster of conditions including obesity, high blood sugar, and insulin resistance that raises the risk of diabetes, fatty liver disease, and, less obviously,...","date_modified":"2026-06-13T19:49:12Z"},{"id":"https://guaninemedical.com/become-a-member/f/the-molecular-switch-that-keeps-your-immune-system-in-check","html_content":"

Your immune system faces a tricky balancing act every day. It needs to stay quiet enough to avoid attacking your own tissues, yet be ready to spring into action the moment a virus shows up. A new study published in Scien...

","url":"https://guaninemedical.com/become-a-member/f/the-molecular-switch-that-keeps-your-immune-system-in-check","title":"The Molecular Switch That Keeps Your Immune System in Check","summary":"Your immune system faces a tricky balancing act every day. It needs to stay quiet enough to avoid attacking your own tissues, yet be ready to spring into action the moment a virus shows up. A new study published in Scien...","date_modified":"2026-06-07T00:08:57Z"},{"id":"https://guaninemedical.com/become-a-member/f/destroying-undruggable-cancer-proteins-from-the-inside","html_content":"

Cancer biology is full of proteins that scientists know are dangerous but can't easily target with drugs. The classic approach to developing a cancer drug is finding a molecule that fits snugly into a pocket on a disease...

","url":"https://guaninemedical.com/become-a-member/f/destroying-undruggable-cancer-proteins-from-the-inside","title":"Destroying Undruggable Cancer Proteins From the Inside","summary":"Cancer biology is full of proteins that scientists know are dangerous but can't easily target with drugs. The classic approach to developing a cancer drug is finding a molecule that fits snugly into a pocket on a disease...","date_modified":"2026-06-04T04:06:14Z"},{"id":"https://guaninemedical.com/become-a-member/f/g-quadruplexes-and-the-architecture-of-disease","html_content":"

For decades, the double helix has served as biology's most iconic image of DNA structure — elegant, stable, and predictable. But inside living cells, nucleic acids are far less disciplined. They twist, fold, and buckle i...

","url":"https://guaninemedical.com/become-a-member/f/g-quadruplexes-and-the-architecture-of-disease","title":"G-Quadruplexes and the Architecture of Disease","summary":"For decades, the double helix has served as biology's most iconic image of DNA structure — elegant, stable, and predictable. But inside living cells, nucleic acids are far less disciplined. They twist, fold, and buckle i...","date_modified":"2026-05-30T02:25:33Z"},{"id":"https://guaninemedical.com/become-a-member/f/a-school-morning-that-never-ended-%E2%80%93-a-poem-for-minab","html_content":"

Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world since they were first i...

","url":"https://guaninemedical.com/become-a-member/f/a-school-morning-that-never-ended-%E2%80%93-a-poem-for-minab","title":"Techniques to Detect Unusual Nucleic Acid Structures","summary":"Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world since they were first i...","date_modified":"2026-04-05T19:48:26Z"},{"id":"https://guaninemedical.com/become-a-member/f/cures-are-just-over-the-horizon-for-sickle-cell-disease-in-ksa","html_content":"

Therapeutic oligonucleotides are powerful and versatile biopolymers developed as drugs for clinical applications due to their straightforward synthesis and design. On the other hand, many of their most promising applicat...

","url":"https://guaninemedical.com/become-a-member/f/cures-are-just-over-the-horizon-for-sickle-cell-disease-in-ksa","title":"Therapeutic Benefits of Mirrored Oligonucleotides in Cancer","summary":"Therapeutic oligonucleotides are powerful and versatile biopolymers developed as drugs for clinical applications due to their straightforward synthesis and design. On the other hand, many of their most promising applicat...","date_modified":"2024-10-23T03:38:54Z"}]}